マイクロキャピラリー電気泳動システム ChipGenie edition E2

カチオンとアニオンの高速検出が可能な，小型のマイクロキャピラリー電気泳動装置です。非接触電気伝導度検出(C⁴D)を採用しており，検出電極を汚染・消耗することなく検体を分離します。
装置本体とお手持ちのPCをUSBで接続し，付属のソフトウェアで制御することができます。

ChipGenie edition E2 幅広いサンプルやアプリケーションに対応可能。

電気泳動システムスターターキット チップ，アクセサリ，標準溶液がセットになった便利なキット。

有機酸(アニオン)の分離例 BGE:50 mM MES / 25 mM His(pH 6.1)

血中イオン(カチオン)の分離例 (左)K-Na-Li混合液，(右)Li較正

Publication list: microfluidic ChipShopのマイクロ流体チップを用いた研究成果 (抜粋)

[POCT (Point of care testing)]
▶A low-cost integrated biosensing platform based on SiN nanophotonics for biomarker detection in urine. D Martens et al., Anal. Methods, 2018, 10, 3066 (Keywords: Biomarker detection, Nanophotonic sensor, POC)
▶Label-Free and Real-Time Detection of Tuberculosis in Human Urine Samples Using a Nanophotonic Point-of-Care Platform. P Ramirez-Priego et al., ACS Sens. 2018, 3, 10, 2079-2086 (Keywords: Immunology, Anatomy, Sensors)
▶Microfluidic Cartridges for Automated, Point-of-Care Blood Cell Counting. S Smith et al., SLAS TECHNOLOGY: Translating Life Sciences Innovation, 22(2), 176-185 (Keywords: Microfluidics, Point-of-care diagnostics, Blood cell counting)
▶Blister pouches for effective reagent storage on microfluidic chips for blood cell counting. S Smith et al., Microfluidics and Nanofluidics, 20(12), December 2016 (Keywords: Blister pouch, Microfluidics, Reagent storage)

[POCT (Point of care testing)とマイクロ流体デバイスの標準化の検討]
▶Accelerating innovation and commercialization through standardization of microfluidic-based medical devices. D Reyes et al., Lab Chip, 2021, 21, 9-21 (Keywords: Microfluidics, Standardization)

[Organ-on-a-chip / Microphysiological systems]
▶A new organ-on-chip platform for physiological relevant in-vitro reproduction of the blood–brain barrier. H Kiessling et al., MicroTAS 2015 (Keywords: Organ-on-a-chip, Dielectrophoresis, Polymer microfabrication)
▶Monitoring cytochrome P450 activity in living hepatocytes by chromogenic substrates in response to drug treatment or during cell maturation. J Theobald et al., Arch Toxicol 92, 1133-1149 (2018) (Keywords: Hepatocytes, Fluorescence, CYP450 enzymes)
▶A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. M Maurer et al., Biomaterials, Volume 220, November 2019, 119396 (Keywords: Microphysiological system, Gut-on-chip, Microbiota)
▶Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. H Pein et al., Proc. of SPIE Vol. 10699 106990U-1 (Keywords: Granulocytes, Inflammatory diseases, Lipids)
▶In vitro metabolic activation of vitamin D3 by using a multicompartment microfuidic liverkidney organ on chip platform. J Theobald et al., Scientific Reports | (2019) 9:4616 (Keywords: Lab-on-a-chip, Multicellular systems)
▶Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model. S Deinhardt-Emmer, K Rennert et al., Biofabrication 12 (2020) 025012 (Keywords: Immune-responsive model, inflammatory response)

[Immunoassay / イムノアッセイ]
▶An integrated homogeneous SPARCL™ immunoassay for rapid biomarker detection on a chip. N Sandetskaya et al., Anal. Methods, 19, 2542-2550, 2019. (Keywords: Immunoassay, Quantitative detection, biomarker)

[Droplet generation / 液滴生成]
▶High-Throughput Optimization of Recombinant Protein Production in Microfluidic Gel Beads. M Napiorkowska et al., Small 2021, 17, 2005523 (Keywords: Droplet microfluidics, Gel microdroplets, High-throughput screening)